Experimental cancer vaccine combo has 100% success rate in mice

A promising new cancer vaccine has shown the ability to ward off, and stop the return, of aggressive cancer cells.

By adding a molecule called Diprovocim to a vaccine, researchers report being able to draw cancer-fighting cells to tumor sites in mice. It works in conjunction with other cancer-treatment therapies to stop some aggressive, and often deadly, forms of cancer, like melanoma.

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“This co-therapy produced a complete response — a curative response — in the treatment of melanoma,” said the study’s co-author, Professor Dr. Dale Boger of Scripps Research.

The vaccine also prompts the immune system to produce the same targeted response should the cells ever return , according to Boger and Nobel laureate Bruce Beutler, of University of Texas Southern. “Just as a vaccine can train the body to fight off external pathogens, this vaccine trains the immune system to go after a tumor,” Professor Boger writes.

So far the research has been tested against a particularly aggressive form of melanoma. After being split into three groups — eight receiving the vaccine, eight receiving the vaccine plus Diprovocim, and eight receiving the vaccine plus an adjuvant called alum — the researchers discovered the mice given the combination of Diprovocim and the vaccine had a 100 percent survival rate of over 54 days. Mice given the cancer vaccine and alum had a 25 percent survival rate, and those given just the vaccine had a zero percent survival rate.

When researchers attempted to re-introduce the tumor in mice, “it wouldn’t take,” says Professor Boger. “The animal is already vaccinated against it.”

It’s still early days, but the next steps, according to Boger and Beutler, is to do further pre-clinical testing with the vaccine and study its effectiveness when paired with other cancer therapies.

via Drug Target Review

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice
on Proceedings of the National Academies of Sciences in the United States of America

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